MagBio’s New Long-Read Sequencing Technology: SFD-HT

SFD-HT (Short Fragment Depletor – High Throughput) is MagBio Genomics’ patent-pending, tunable paramagnetic bead-based reagent technology designed to optimize DNA input for long-read sequencing workflows. By selectively depleting short DNA fragments, SFD-HT enriches high-integrity long DNA molecules that improve average read length and maximize sequencing efficiency across complex genomic applications.

Designed for both manual and automated workflows, SFD-HT integrates seamlessly from benchtop research to high-throughput sequencing environments. The technology is compatible with Oxford Nanopore Technologies (ONT), PacBio, and emerging long-read sequencing platforms, and is available for early evaluation and OEM integration discussions.

Applications Include:

• Structural Variant Analysis: Detect large deletions, inversions, duplications, and complex rearrangements with long contiguous reads.
• De Novo Genome Assembly: Improve assembly continuity and resolve repetitive genomic regions.
• Cancer Genomics Research: Support detection of structural alterations and fusion events.
• Rare Disease Research: Preserve long-range genomic information for variant phasing and structural variant discovery.
• Metagenomics and Microbiome Studies: Improve strain-level differentiation and metagenome assembly quality.

By enabling tunable depletion of shorter DNA fragments, SFD-HT gives researchers greater control over DNA optimization for long-read sequencing and library preparation workflows.

SFD-HT expands MagBio’s portfolio of advanced paramagnetic bead-based technologies designed to improve genomic workflow performance and advance next-generation sequencing innovation.

Available Through:

• Direct supply
• Distribution partnerships
• OEM integration
• Licensing opportunities
• White-label collaborations

Learn More About SFD-HT Early Adoption & Collaboration Inquiry