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SFD-HT (Short Fragment Depletor – High Throughput)
DNA Size Redistribution Reagent for Long-Read Sequencing
SFD-HT is a patent-pending magnetic bead–based DNA purification and size redistribution reagent designed to optimize high molecular weight (HMW) DNA and genomic DNA input for long-read sequencing workflows. Applied after DNA isolation, SFD-HT selectively reduces short DNA fragments while enriching longer molecules that improve sequencing library quality and long-read output.
Compatible with Oxford Nanopore® and PacBio® workflows, SFD-HT enables tunable depletion of fragments below 10 kb, 25 kb, or 40 kb using an automation-friendly magnetic bead workflow.
Unlike traditional size selection methods such as gel extraction, BluePippin™, and fixed-threshold cleanup reagents, SFD-HT provides a flexible and scalable approach to DNA size redistribution for improved long-read sequencing performance.
Performance Data SFD-HT Early Adopter & Collaboration Program Form
Key Benefits
- Tunable depletion below 10 kb, 25 kb, or 40 kb
- Improves long-read sequencing library quality
- Preserves ultra-long DNA fragments
- Automation-compatible magnetic bead workflow
- No centrifugation required
- Optimized for Oxford Nanopore® and PacBio® platforms
Applications
- Long-read whole genome sequencing
- Structural variant analysis
- Genome assembly
- Ultra-long read sequencing
- Long-read metagenomics
Recommended Workflow
- Isolate HMW DNA and gDNA
- Apply SFD-HT for short-fragment depletion
- Proceed to long-read library preparation and sequencing
Interested in testing SFD-HT?
Then join the SFD-HT Early Adopter & Collaboration Program
MagBio Genomics invites qualified laboratories and biotech companies to participate in our SFD-HT Early Adopter & Collaboration Program. As an early partner, you will test SFD-HT during its innovation, development and testing phase, providing feedback that directly shapes the product and its applications in long-read sequencing.
How your Lab will Benefit from the Collaboration Program.
- Early Access to SFD-HT
Integrate this new short-fragment depletion technology into your long-read workflows ahead of the broader market, gaining a competitive edge. - Direct Collaboration with MagBio R&D
Work directly with our scientists to shape the product's development, optimize performance on your samples, and influence future product features. - Discounted Pricing at Launch
Secure a special discounted rate when SFD-HT is fully launched, in recognition of your contribution as an early collaborator, ensuring favorable long-term cost-effectiveness. - Enhanced Visibility
Be recognized as a contributor to next-generation long-read sequencing innovation through collaborative opportunities.